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Target
Muscarinic acetylcholine receptor M4
Ligand
BDBM48069
Substrate
n/a
Meas. Tech.
Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator(PAM): Analog Potency
EC50
2750±n/a nM
Citation
 PubChem, PC Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator(PAM): Analog Potency PubChem Bioassay (2010)[AID] 
Target
Name:
Muscarinic acetylcholine receptor M4
Synonyms:
ACM4_RAT | Cholinergic, muscarinic M4 | Chrm-4 | Chrm4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52841.70
Organism:
RAT
Description:
Cholinergic, muscarinic M4 CHRM4 RAT::P08485
Residue:
477
Sequence:
MNFTPVNGSSANQSVRLVTAAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLGCADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKPSIKKPPPGGASREELRNGKLEEAPPPALPPPPRPVPDKDTSNESSSGSATQNTKERPPTELSTAEATTPALPAPTLQPRTLNPASKWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
  
Inhibitor
Name:
BDBM48069
Synonyms:
3-amino-N-(2,5-difluorobenzyl)-6-[3-(dimethylamino)propoxy]-4-methyl-thieno[2,3-b]pyridine-2-carboxamide | 3-amino-N-[(2,5-difluorophenyl)methyl]-6-[3-(dimethylamino)propoxy]-4-methyl-2-thieno[2,3-b]pyridinecarboxamide | 3-amino-N-[(2,5-difluorophenyl)methyl]-6-[3-(dimethylamino)propoxy]-4-methylthieno[2,3-b]pyridine-2-carboxamide | 3-azanyl-N-[[2,5-bis(fluoranyl)phenyl]methyl]-6-[3-(dimethylamino)propoxy]-4-methyl-thieno[2,3-b]pyridine-2-carboxamide | VU0359451 | cid_45142478
Type:
Small organic molecule
Emp. Form.:
C21H24F2N4O2S
Mol. Mass.:
434.503
SMILES:
CN(C)CCCOc1cc(C)c2c(N)c(sc2n1)C(=O)NCc1cc(F)ccc1F
Structure:
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