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Target
Muscarinic acetylcholine receptor M4
Ligand
BDBM48072
Substrate
n/a
Meas. Tech.
Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator(PAM): Analog Potency
EC50
7150±n/a nM
Citation
 PubChem, PC Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator(PAM): Analog Potency PubChem Bioassay (2010)[AID] 
Target
Name:
Muscarinic acetylcholine receptor M4
Synonyms:
ACM4_RAT | Cholinergic, muscarinic M4 | Chrm-4 | Chrm4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52841.70
Organism:
RAT
Description:
Cholinergic, muscarinic M4 CHRM4 RAT::P08485
Residue:
477
Sequence:
MNFTPVNGSSANQSVRLVTAAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLGCADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKPSIKKPPPGGASREELRNGKLEEAPPPALPPPPRPVPDKDTSNESSSGSATQNTKERPPTELSTAEATTPALPAPTLQPRTLNPASKWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
  
Inhibitor
Name:
BDBM48072
Synonyms:
3-amino-4-methyl-6-(2-morpholin-4-ylethoxy)-N-propan-2-ylthieno[2,3-b]pyridine-2-carboxamide | 3-amino-4-methyl-6-[2-(4-morpholinyl)ethoxy]-N-propan-2-yl-2-thieno[2,3-b]pyridinecarboxamide | 3-amino-N-isopropyl-4-methyl-6-(2-morpholinoethoxy)thieno[2,3-b]pyridine-2-carboxamide | 3-azanyl-4-methyl-6-(2-morpholin-4-ylethoxy)-N-propan-2-yl-thieno[2,3-b]pyridine-2-carboxamide | VU0359459 | cid_45142482
Type:
Small organic molecule
Emp. Form.:
C18H26N4O3S
Mol. Mass.:
378.489
SMILES:
CC(C)NC(=O)c1sc2nc(OCCN3CCOCC3)cc(C)c2c1N
Structure:
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