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Target
ATP-sensitive inward rectifier potassium channel 1
Ligand
BDBM265547
Substrate
n/a
Meas. Tech.
Thallium Flux Assay
IC50
4.30±n/a nM
Citation
 Biswas, D; Ding, F; Dong, S; Gu, X; Jiang, J; Pasternak, A; Suzuki, T; Vacca, J; Xu, S Inhibitors of the renal outer medullary potassium channel US Patent  US9718808 Publication Date 8/1/2017 
Target
Name:
ATP-sensitive inward rectifier potassium channel 1
Synonyms:
ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44809.08
Organism:
Homo sapiens (Human)
Description:
gi_223460826
Residue:
391
Sequence:
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQSRFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTPCVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGETIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLYNEKDVRARMKRGYDNPNFILSEVNETDDTKM
  
Inhibitor
Name:
BDBM265547
Synonyms:
US9718808, 51
Type:
Small organic molecule
Emp. Form.:
C24H28N6O3
Mol. Mass.:
448.5175
SMILES:
CC1=C(COC1=O)N1CC[C@@]2(CC[C@@H](CC2)NCc2ccc-3c(CCc4nnnn-34)c2)C1=O |r,wU:10.35,wD:13.17,t:1,(7.21,2.52,;7.98,1.18,;7.5,-.28,;8.75,-1.19,;9.99,-.28,;9.52,1.18,;10.29,2.52,;6.17,-1.05,;5.69,-2.52,;4.15,-2.52,;3.68,-1.05,;2.59,-2.14,;1.1,-1.74,;.7,-.25,;1.79,.83,;3.28,.44,;-.79,.14,;-1.88,-.95,;-3.36,-.55,;-3.76,.94,;-5.25,1.34,;-6.34,.25,;-5.94,-1.24,;-7.03,-2.33,;-8.52,-1.93,;-8.91,-.44,;-10.29,.26,;-10.05,1.78,;-8.53,2.02,;-7.83,.65,;-4.45,-1.64,;4.92,-.15,;4.92,1.39,)|
Structure:
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