Reaction Details Report a problem with these data
Target
D(1B) dopamine receptor
Ligand
BDBM48945
Substrate
n/a
Meas. Tech.
Allosteric Modulators of D1 Receptors: Dose-dependent Counterscreen
EC50
0.00851±n/a nM
Citation
 PubChem, PC Allosteric Modulators of D1 Receptors: Dose-dependent Counterscreen PubChem Bioassay (2007)[AID] 
Target
Name:
D(1B) dopamine receptor
Synonyms:
D(5) dopamine receptor | D1beta dopamine receptor | DOPAMINE D5 | DRD1B | DRD1L2 | DRD5 | DRD5_HUMAN | dopamine receptor D5
Type:
Protein
Mol. Mass.:
52943.41
Organism:
Homo sapiens (Human)
Description:
P21918
Residue:
477
Sequence:
MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAACAPDTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAFNADFQKVFAQLLGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTPGNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEGEISLDKITPFTPNGFH
  
Inhibitor
Name:
BDBM48945
Synonyms:
(2Z)-2-(7-hydroxy-6-methoxy-3,3-dimethyl-2,4-dihydroisoquinolin-1-ylidene)acetic acid ethyl ester | MLS000090019 | SMR000024637 | cid_5292846 | ethyl (2Z)-(7-hydroxy-6-methoxy-3,3-dimethyl-3,4-dihydroisoquinolin-1(2H)-ylidene)acetate | ethyl (2Z)-2-(6-methoxy-3,3-dimethyl-7-oxidanyl-2,4-dihydroisoquinolin-1-ylidene)ethanoate | ethyl (2Z)-2-(7-hydroxy-6-methoxy-3,3-dimethyl-2,4-dihydroisoquinolin-1-ylidene)acetate
Type:
Small organic molecule
Emp. Form.:
C16H21NO4
Mol. Mass.:
291.3422
SMILES:
CCOC(=O)CC1=NC(C)(C)Cc2cc(OC)c(O)cc12 |t:6|
Structure:
Search PDB for entries with ligand similarity: