Target
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4
Ligand
BDBM267061
Substrate
n/a
Meas. Tech.
PFKFB4 Assay
IC50
1400±n/a nM
Citation
 Martinsson, JFaernegardh, KJoensson, MRingom, R Bisarylsulfonamides useful in the treatment of inflammation and cancer US Patent  US9718809 Publication Date 8/1/2017 
Target
Name:
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4
Synonyms:
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) | F264_HUMAN | PFKFB4
Type:
Enzyme
Mol. Mass.:
54039.68
Organism:
Homo sapiens (Human)
Description:
Q16877
Residue:
469
Sequence:
MASPRELTQNPLKKIWMPYSNGRPALHACQRGVCMTNCPTLIVMVGLPARGKTYISKKLTRYLNWIGVPTREFNVGQYRRDVVKTYKSFEFFLPDNEEGLKIRKQCALAALRDVRRFLSEEGGHVAVFDATNTTRERRATIFNFGEQNGYKTFFVESICVDPEVIAANIVQVKLGSPDYVNRDSDEATEDFMRRIECYENSYESLDEDLDRDLSYIKIMDVGQSYVVNRVADHIQSRIVYYLMNIHVTPRSIYLCRHGESELNLKGRIGGDPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAEALGVPYEQWKVLNEIDAGVCEEMTYEEIQDNYPLEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKAAEQLPYLKCPLHTVLKLTPVAYGCKVESIFLNVAAVNTHRDRPQNVDISRPPEEALVTVPAHQ
  
Inhibitor
Name:
BDBM267061
Synonyms:
2-Methoxy-1-(methoxymethyl)ethyl 4-{[(3,5-dichlorophenyl)sulfonyl]amino}-2-hydroxybenzoate | US9718809, 191
Type:
Small organic molecule
Emp. Form.:
C18H19Cl2NO7S
Mol. Mass.:
464.317
SMILES:
COCC(COC)OC(=O)c1ccc(NS(=O)(=O)c2cc(Cl)cc(Cl)c2)cc1O
Structure:
Search PDB for entries with ligand similarity: