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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM50226
Substrate
n/a
Meas. Tech.
Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors
IC50
400±n/a nM
Citation
 PubChem, PC Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors PubChem Bioassay (2008)[AID] 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM50226
Synonyms:
(4Z)-1-(3-fluorophenyl)-4-(2-ketoindolin-3-ylidene)pyrazolidine-3,5-quinone | (4Z)-1-(3-fluorophenyl)-4-(2-oxidanylidene-1H-indol-3-ylidene)pyrazolidine-3,5-dione | (4Z)-1-(3-fluorophenyl)-4-(2-oxo-1H-indol-3-ylidene)pyrazolidine-3,5-dione | 1-(3-fluorophenyl)-4-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)-3,5-pyrazolidinedione | MLS000580068 | SMR000199312 | cid_5428579
Type:
Small organic molecule
Emp. Form.:
C17H10FN3O3
Mol. Mass.:
323.278
SMILES:
Fc1cccc(c1)N1NC(=O)\C(C1=O)=C1\C(=O)Nc2ccccc12
Structure:
Search PDB for entries with ligand similarity: