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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43416
Substrate
n/a
Meas. Tech.
E3 Ligase_Mutant_Dose Response
EC50
41600±n/a nM
Citation
 PubChem, PC E3 Ligase_Mutant_Dose Response PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43416
Synonyms:
MLS000375336 | N-[1-(1-adamantyl)ethyl]-2-(4,5-dichloro-6-keto-pyridazin-1-yl)acetamide | N-[1-(1-adamantyl)ethyl]-2-(4,5-dichloro-6-oxo-1-pyridazinyl)acetamide | N-[1-(1-adamantyl)ethyl]-2-(4,5-dichloro-6-oxopyridazin-1-yl)acetamide | N-[1-(1-adamantyl)ethyl]-2-[4,5-bis(chloranyl)-6-oxidanylidene-pyridazin-1-yl]ethanamide | SMR000254589 | cid_4811966
Type:
Small organic molecule
Emp. Form.:
C18H23Cl2N3O2
Mol. Mass.:
384.3
SMILES:
[H]C12CC3([H])CC([H])(C1)CC(C2)(C3)C(C)NC(=O)Cn1ncc(Cl)c(Cl)c1=O |TLB:8:6:12:1.11.2,8:1:12:6.9.5,THB:5:6:11:3.12.2|
Structure:
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