Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43475
Substrate
n/a
Meas. Tech.
E3 Ligase_WT_Dose Response
EC50
18070±n/a nM
Citation
 PubChem, PC E3 Ligase_WT_Dose Response PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43475
Synonyms:
4-amino-2-[(E)-3-(3-bromophenyl)-1-oxoprop-2-enyl]isoindole-1,3-dione | 4-amino-2-[(E)-3-(3-bromophenyl)acryloyl]isoindoline-1,3-quinone | 4-amino-2-[(E)-3-(3-bromophenyl)prop-2-enoyl]isoindole-1,3-dione | 4-azanyl-2-[(E)-3-(3-bromophenyl)prop-2-enoyl]isoindole-1,3-dione | MLS000516708 | SMR000342877 | cid_5854374
Type:
Small organic molecule
Emp. Form.:
C17H11BrN2O3
Mol. Mass.:
371.185
SMILES:
Nc1cccc2C(=O)N(C(=O)\C=C\c3cccc(Br)c3)C(=O)c12
Structure:
Search PDB for entries with ligand similarity: