Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM43784
Substrate
n/a
Meas. Tech.
SAR assay for compounds activating TNAP in the presence of 100 mM DEA performed in a luminescence assay
EC50
17800±n/a nM
Citation
 PubChem, PC SAR assay for compounds activating TNAP in the presence of 100 mM DEA performed in a luminescence assay PubChem Bioassay (2009)[AID] 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM43784
Synonyms:
1-[(1,3-dimethylpyrazol-4-yl)carbonylamino]-3-(4-methylphenyl)thiourea | 1-[(1,3-dimethylpyrazole-4-carbonyl)amino]-3-(4-methylphenyl)thiourea | 1-[(1,3-dimethylpyrazole-4-carbonyl)amino]-3-(p-tolyl)thiourea | 1-[[(1,3-dimethyl-4-pyrazolyl)-oxomethyl]amino]-3-(4-methylphenyl)thiourea | MLS-0101838.0001 | cid_842630
Type:
Small organic molecule
Emp. Form.:
C14H17N5OS
Mol. Mass.:
303.383
SMILES:
Cc1nn(C)cc1C(=O)NNC(=S)Nc1ccc(C)cc1
Structure:
Search PDB for entries with ligand similarity: