Reaction Details Report a problem with these data
Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM43786
Substrate
n/a
Meas. Tech.
SAR assay for compounds activating TNAP in the presence of 100 mM DEA performed in a luminescence assay
EC50
10200±n/a nM
Citation
 PubChem, PC SAR assay for compounds activating TNAP in the presence of 100 mM DEA performed in a luminescence assay PubChem Bioassay (2009)[AID] 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM43786
Synonyms:
1-[(5-bromanylfuran-2-yl)carbonylamino]-3-(2,5-dimethylphenyl)thiourea | 1-[(5-bromo-2-furoyl)amino]-3-(2,5-dimethylphenyl)thiourea | 1-[(5-bromofuran-2-carbonyl)amino]-3-(2,5-dimethylphenyl)thiourea | 1-[[(5-bromo-2-furanyl)-oxomethyl]amino]-3-(2,5-dimethylphenyl)thiourea | MLS-0092828.0001 | cid_998878
Type:
Small organic molecule
Emp. Form.:
C14H14BrN3O2S
Mol. Mass.:
368.249
SMILES:
Cc1ccc(C)c(NC(=S)NNC(=O)c2ccc(Br)o2)c1
Structure:
Search PDB for entries with ligand similarity: