Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM39754
Substrate
n/a
Meas. Tech.
SAR assay for compounds activating TNAP in the presence of 100 mM DEA performed in a luminescence assay
EC50
38000±n/a nM
Citation
 PubChem, PC SAR assay for compounds activating TNAP in the presence of 100 mM DEA performed in a luminescence assay PubChem Bioassay (2009)[AID] 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM39754
Synonyms:
1-benzyl-N'-[(1-ethyl-5-methyl-1H-pyrazol-4-yl)methylene]-2,3-dimethyl-1H-indole-5-carbohydrazide | 1-benzyl-N-[(1-ethyl-5-methyl-pyrazol-4-yl)methyleneamino]-2,3-dimethyl-indole-5-carboxamide | 1-benzyl-N-[(1-ethyl-5-methylpyrazol-4-yl)methylideneamino]-2,3-dimethylindole-5-carboxamide | 1-benzyl-N-[(E)-(1-ethyl-5-methyl-pyrazol-4-yl)methyleneamino]-2,3-dimethyl-indole-5-carboxamide | MLS000537141 | N-[(1-ethyl-5-methyl-4-pyrazolyl)methylideneamino]-2,3-dimethyl-1-(phenylmethyl)-5-indolecarboxamide | N-[(1-ethyl-5-methyl-pyrazol-4-yl)methylideneamino]-2,3-dimethyl-1-(phenylmethyl)indole-5-carboxamide | SMR000159897 | cid_1227727
Type:
Small organic molecule
Emp. Form.:
C25H27N5O
Mol. Mass.:
413.5148
SMILES:
CCn1ncc(C=NNC(=O)c2ccc3n(Cc4ccccc4)c(C)c(C)c3c2)c1C |w:7.7|
Structure:
Search PDB for entries with ligand similarity: