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Target
Mucolipin-3
Ligand
BDBM46792
Substrate
n/a
Meas. Tech.
Fluorescence counterscreen assay for TRPN1 agonists: dose response cell-based high-throughput screening assay to identify agonists of the transient receptor potential channel ML3 (TRPML3)
EC50
8880±n/a nM
Citation
 PubChem, PC Fluorescence counterscreen assay for TRPN1 agonists: dose response cell-based high-throughput screening assay to identify agonists of the transient receptor potential channel ML3 (TRPML3) PubChem Bioassay (2009)[AID] 
Target
Name:
Mucolipin-3
Synonyms:
MCLN3_HUMAN | MCOLN3 | MCOLN3 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
64244.09
Organism:
Homo sapiens (Human)
Description:
Q8TDD5
Residue:
553
Sequence:
MADPEVVVSSCSSHEEENRCNFNQQTSPSEELLLEDQMRRKLKFFFMNPCEKFWARGRKPWKLAIQILKIAMVTIQLVLFGLSNQMVVAFKEENTIAFKHLFLKGYMDRMDDTYAVYTQSDVYDQLIFAVNQYLQLYNVSVGNHAYENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDPEIETECFFVEPDEPFHIGTPAENKLNLTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIRECKDWHVSGSIQKNTHYMMIFDAFVILTCLVSLILCIRSVIRGLQLQQEFVNFFLLHYKKEVSVSDQMEFVNGWYIMIIISDILTIIGSILKMEIQAKSLTSYDVCSILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSLINGDDMFATFAKMQQKSYLVWLFSRIYLYSFISLFIYMILSLFIALITDTYETIKQYQQDGFPETELRTFISECKDLPNSGKYRLEDDPPVSLFCCCKK
  
Inhibitor
Name:
BDBM46792
Synonyms:
2-(1,3-dihydrobenzimidazol-2-ylidene)-3-(3,5-dimethoxy-4-oxidanylidene-cyclohexa-2,5-dien-1-ylidene)propanenitrile | 2-(1,3-dihydrobenzimidazol-2-ylidene)-3-(3,5-dimethoxy-4-oxo-1-cyclohexa-2,5-dienylidene)propanenitrile | 2-(1,3-dihydrobenzimidazol-2-ylidene)-3-(3,5-dimethoxy-4-oxocyclohexa-2,5-dien-1-ylidene)propanenitrile | 2-(1,3-dihydrobenzimidazol-2-ylidene)-3-(4-keto-3,5-dimethoxy-cyclohexa-2,5-dien-1-ylidene)propionitrile | MLS000716138 | SMR000277655 | cid_5335875
Type:
Small organic molecule
Emp. Form.:
C18H15N3O3
Mol. Mass.:
321.33
SMILES:
COc1cc(C=C(C#N)c2nc3ccccc3[nH]2)cc(OC)c1O
Structure:
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