Reaction Details Report a problem with these data
Target
Dual specificity protein phosphatase 3
Ligand
BDBM51789
Substrate
n/a
Meas. Tech.
Fluorescent assay for identification of compounds that inhibit VHR1
IC50
4920±n/a nM
Citation
 PubChem, PC Fluorescent assay for identification of compounds that inhibit VHR1 PubChem Bioassay (2009)[AID] 
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM51789
Synonyms:
2-[(5Z)-5-[1-[2-(3-bromoanilino)-2-keto-ethyl]-2-keto-indolin-3-ylidene]-4-keto-2-thioxo-thiazolidin-3-yl]ethanesulfonic acid | 2-[(5Z)-5-[1-[2-(3-bromoanilino)-2-oxoethyl]-2-oxo-3-indolylidene]-4-oxo-2-sulfanylidene-3-thiazolidinyl]ethanesulfonic acid | 2-[(5Z)-5-[1-[2-(3-bromoanilino)-2-oxoethyl]-2-oxoindol-3-ylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]ethanesulfonic acid | 2-[(5Z)-5-[1-[2-[(3-bromophenyl)amino]-2-oxidanylidene-ethyl]-2-oxidanylidene-indol-3-ylidene]-4-oxidanylidene-2-sulfanylidene-1,3-thiazolidin-3-yl]ethanesulfonic acid | MLS000923796 | SMR000620081 | cid_1637842
Type:
Small organic molecule
Emp. Form.:
C21H16BrN3O6S3
Mol. Mass.:
582.467
SMILES:
OS(=O)(=O)CCN1C(=S)S\C(C1=O)=C1/C(=O)N(CC(=O)Nc2cccc(Br)c2)c2ccccc12
Structure:
Search PDB for entries with ligand similarity: