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Target
Beta-lactamase
Ligand
BDBM51958
Substrate
n/a
Meas. Tech.
Epi-absorbance-based dose response biochemical high throughput screening assay for selective inhibitors of VIM-2 metallo-beta-lactamase
IC50
2622±n/a nM
Citation
 PubChem, PC Epi-absorbance-based dose response biochemical high throughput screening assay for selective inhibitors of VIM-2 metallo-beta-lactamase PubChem Bioassay (2009)[AID] 
Target
Name:
Beta-lactamase
Synonyms:
Beta lactamase
Type:
Enzyme Catalytic Domain
Mol. Mass.:
31513.38
Organism:
Pseudomonas aeruginosa
Description:
gi_114881106
Residue:
286
Sequence:
MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW
  
Inhibitor
Name:
BDBM51958
Synonyms:
2,2-Dimethyl-N-(5-{[(thiophen-2-ylmethyl)-carbamoyl]-methylsulfanyl}-[1,3,4]thiadiazol-2-yl)-propionamide | 2,2-dimethyl-N-[5-[2-oxidanylidene-2-(thiophen-2-ylmethylamino)ethyl]sulfanyl-1,3,4-thiadiazol-2-yl]propanamide | 2,2-dimethyl-N-[5-[2-oxo-2-(thiophen-2-ylmethylamino)ethyl]sulfanyl-1,3,4-thiadiazol-2-yl]propanamide | 2,2-dimethyl-N-[5-[[2-oxo-2-(thiophen-2-ylmethylamino)ethyl]thio]-1,3,4-thiadiazol-2-yl]propanamide | MLS000529634 | N-[5-[[2-keto-2-(2-thenylamino)ethyl]thio]-1,3,4-thiadiazol-2-yl]-2,2-dimethyl-propionamide | SMR000122109 | cid_3220530
Type:
Small organic molecule
Emp. Form.:
C14H18N4O2S3
Mol. Mass.:
370.513
SMILES:
CC(C)(C)C(=O)Nc1nnc(SCC(=O)NCc2cccs2)s1
Structure:
Search PDB for entries with ligand similarity: