Reaction Details Report a problem with these data
Target
Beta-lactamase
Ligand
BDBM51973
Substrate
n/a
Meas. Tech.
Epi-absorbance-based dose response biochemical high throughput screening assay for selective inhibitors of VIM-2 metallo-beta-lactamase
IC50
13281±n/a nM
Citation
 PubChem, PC Epi-absorbance-based dose response biochemical high throughput screening assay for selective inhibitors of VIM-2 metallo-beta-lactamase PubChem Bioassay (2009)[AID] 
Target
Name:
Beta-lactamase
Synonyms:
Beta lactamase
Type:
Enzyme Catalytic Domain
Mol. Mass.:
31513.38
Organism:
Pseudomonas aeruginosa
Description:
gi_114881106
Residue:
286
Sequence:
MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW
  
Inhibitor
Name:
BDBM51973
Synonyms:
(E)-4-(1,3-benzothiazol-2-yl)-5-(2-chloranyl-5-nitro-phenyl)pent-4-enoic acid | (E)-4-(1,3-benzothiazol-2-yl)-5-(2-chloro-5-nitro-phenyl)pent-4-enoic acid | (E)-4-(1,3-benzothiazol-2-yl)-5-(2-chloro-5-nitrophenyl)-4-pentenoic acid | (E)-4-(1,3-benzothiazol-2-yl)-5-(2-chloro-5-nitrophenyl)pent-4-enoic acid | MLS000416514 | SMR000243458 | cid_6236321
Type:
Small organic molecule
Emp. Form.:
C18H13ClN2O4S
Mol. Mass.:
388.825
SMILES:
OC(=O)CC\C(=C/c1cc(ccc1Cl)[N+]([O-])=O)c1nc2ccccc2s1
Structure:
Search PDB for entries with ligand similarity: