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Target
Beta-lactamase
Ligand
BDBM52046
Substrate
n/a
Meas. Tech.
Epi-absorbance-based dose response biochemical high throughput screening assay for selective inhibitors of VIM-2 metallo-beta-lactamase
IC50
16724±n/a nM
Citation
 PubChem, PC Epi-absorbance-based dose response biochemical high throughput screening assay for selective inhibitors of VIM-2 metallo-beta-lactamase PubChem Bioassay (2009)[AID] 
Target
Name:
Beta-lactamase
Synonyms:
Beta lactamase
Type:
Enzyme Catalytic Domain
Mol. Mass.:
31513.38
Organism:
Pseudomonas aeruginosa
Description:
gi_114881106
Residue:
286
Sequence:
MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW
  
Inhibitor
Name:
BDBM52046
Synonyms:
MLS001237880 | N-[5-[2-[(2-chlorophenyl)methylamino]-2-oxidanylidene-ethyl]sulfanyl-1,3,4-thiadiazol-2-yl]cyclopropanecarboxamide | N-[5-[2-[(2-chlorophenyl)methylamino]-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]cyclopropanecarboxamide | N-[5-[[2-[(2-chlorobenzyl)amino]-2-keto-ethyl]thio]-1,3,4-thiadiazol-2-yl]cyclopropanecarboxamide | N-[5-[[2-[(2-chlorophenyl)methylamino]-2-oxoethyl]thio]-1,3,4-thiadiazol-2-yl]cyclopropanecarboxamide | SMR000806407 | cid_8483299
Type:
Small organic molecule
Emp. Form.:
C15H15ClN4O2S2
Mol. Mass.:
382.888
SMILES:
Clc1ccccc1CNC(=O)CSc1nnc(NC(=O)C2CC2)s1
Structure:
Search PDB for entries with ligand similarity: