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Target
Beta-lactamase
Ligand
BDBM51977
Substrate
n/a
Meas. Tech.
Epi-absorbance-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase.
IC50
59640±n/a nM
Citation
 PubChem, PC Epi-absorbance-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase. PubChem Bioassay (2009)[AID] 
Target
Name:
Beta-lactamase
Synonyms:
Beta-lactamase | metallo-beta-lactamase IMP-1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27125.88
Organism:
Pseudomonas aeruginosa
Description:
gi_27368096
Residue:
246
Sequence:
MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN
  
Inhibitor
Name:
BDBM51977
Synonyms:
3-hydroxy-5-(2-pyridinyl)-1-(3-pyridinylmethyl)-4-(2-thienylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one | 3-hydroxy-5-(2-pyridyl)-1-(3-pyridylmethyl)-4-(2-thenoyl)-3-pyrrolin-2-one | 4-hydroxy-2-pyridin-2-yl-1-(pyridin-3-ylmethyl)-3-(thiophene-2-carbonyl)-2H-pyrrol-5-one | 4-hydroxy-3-[oxo(thiophen-2-yl)methyl]-2-(2-pyridinyl)-1-(3-pyridinylmethyl)-2H-pyrrol-5-one | 4-oxidanyl-2-pyridin-2-yl-1-(pyridin-3-ylmethyl)-3-thiophen-2-ylcarbonyl-2H-pyrrol-5-one | MLS000624914 | SMR000293669 | cid_2951255
Type:
Small organic molecule
Emp. Form.:
C20H15N3O3S
Mol. Mass.:
377.416
SMILES:
O=C(C1C(N(Cc2cccnc2)C(=O)C1=O)c1ccccn1)c1cccs1
Structure:
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