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Target
Beta-lactamase
Ligand
BDBM52028
Substrate
n/a
Meas. Tech.
Epi-absorbance-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase.
IC50
59640±n/a nM
Citation
 PubChem, PC Epi-absorbance-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase. PubChem Bioassay (2009)[AID] 
Target
Name:
Beta-lactamase
Synonyms:
Beta-lactamase | metallo-beta-lactamase IMP-1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27125.88
Organism:
Pseudomonas aeruginosa
Description:
gi_27368096
Residue:
246
Sequence:
MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN
  
Inhibitor
Name:
BDBM52028
Synonyms:
2,6-bis(fluoranyl)-N-[5-[2-oxidanylidene-2-[(phenylmethyl)amino]ethyl]sulfanyl-1,3,4-thiadiazol-2-yl]benzamide | 2,6-difluoro-N-[5-[[2-oxo-2-[(phenylmethyl)amino]ethyl]thio]-1,3,4-thiadiazol-2-yl]benzamide | MLS001221603 | N-[5-(Benzylcarbamoyl-methylsulfanyl)-[1,3,4]thiadiazol-2-yl]-2,6-difluoro-benzamide | N-[5-[2-(benzylamino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]-2,6-difluorobenzamide | N-[5-[[2-(benzylamino)-2-keto-ethyl]thio]-1,3,4-thiadiazol-2-yl]-2,6-difluoro-benzamide | SMR000601771 | cid_3623360
Type:
Small organic molecule
Emp. Form.:
C18H14F2N4O2S2
Mol. Mass.:
420.456
SMILES:
Fc1cccc(F)c1C(=O)Nc1nnc(SCC(=O)NCc2ccccc2)s1
Structure:
Search PDB for entries with ligand similarity: