Reaction Details Report a problem with these data
Target
Beta-lactamase
Ligand
BDBM37863
Substrate
n/a
Meas. Tech.
FRET-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase.
IC50
59640±n/a nM
Citation
 PubChem, PC FRET-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase. PubChem Bioassay (2009)[AID] 
Target
Name:
Beta-lactamase
Synonyms:
Beta-lactamase | metallo-beta-lactamase IMP-1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27125.88
Organism:
Pseudomonas aeruginosa
Description:
gi_27368096
Residue:
246
Sequence:
MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN
  
Inhibitor
Name:
BDBM37863
Synonyms:
N-(5-keto-2-tosyl-3-pyrazolin-3-yl)thiophene-2-carboxamide | N-[2-(4-methylphenyl)sulfonyl-5-oxidanylidene-1H-pyrazol-3-yl]thiophene-2-carboxamide | N-[2-(4-methylphenyl)sulfonyl-5-oxo-1H-pyrazol-3-yl]-2-thiophenecarboxamide | N-[2-(4-methylphenyl)sulfonyl-5-oxo-1H-pyrazol-3-yl]thiophene-2-carboxamide | PC-0095740 | PCMD-CC-MCM-26 | cid_11834391
Type:
Small organic molecule
Emp. Form.:
C15H13N3O4S2
Mol. Mass.:
363.411
SMILES:
Cc1ccc(cc1)S(=O)(=O)n1[nH]c(=O)cc1NC(=O)c1cccs1
Structure:
Search PDB for entries with ligand similarity: