Target
Beta-lactamase
Ligand
BDBM51981
Substrate
n/a
Meas. Tech.
FRET-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase.
IC50
59640±n/a nM
Citation
 PubChem, PC FRET-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase. PubChem Bioassay (2009)[AID] 
Target
Name:
Beta-lactamase
Synonyms:
Beta-lactamase | metallo-beta-lactamase IMP-1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27125.88
Organism:
Pseudomonas aeruginosa
Description:
gi_27368096
Residue:
246
Sequence:
MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN
  
Inhibitor
Name:
BDBM51981
Synonyms:
1-[4-[4-[(6-amino-2,5-dimethyl-3-imidazo[4,5-b]pyridinyl)methyl]phenyl]phenyl]ethanone | 1-[4-[4-[(6-amino-2,5-dimethyl-imidazo[4,5-b]pyridin-3-yl)methyl]phenyl]phenyl]ethanone | 1-[4-[4-[(6-amino-2,5-dimethylimidazo[4,5-b]pyridin-3-yl)methyl]phenyl]phenyl]ethanone | 1-[4-[4-[(6-azanyl-2,5-dimethyl-imidazo[4,5-b]pyridin-3-yl)methyl]phenyl]phenyl]ethanone | MLS000718474 | SMR000290742 | cid_1437874
Type:
Small organic molecule
Emp. Form.:
C23H22N4O
Mol. Mass.:
370.447
SMILES:
CC(=O)c1ccc(cc1)-c1ccc(Cn2c(C)nc3cc(N)c(C)nc23)cc1
Structure:
Search PDB for entries with ligand similarity: