Reaction Details Report a problem with these data
Target
Beta-lactamase
Ligand
BDBM51988
Substrate
n/a
Meas. Tech.
FRET-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase.
IC50
59640±n/a nM
Citation
 PubChem, PC FRET-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase. PubChem Bioassay (2009)[AID] 
Target
Name:
Beta-lactamase
Synonyms:
Beta-lactamase | metallo-beta-lactamase IMP-1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27125.88
Organism:
Pseudomonas aeruginosa
Description:
gi_27368096
Residue:
246
Sequence:
MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN
  
Inhibitor
Name:
BDBM51988
Synonyms:
3-(4-tert-butylbenzyl)oxy-2-thenoic acid | 3-[(4-tert-butylphenyl)methoxy]-2-thiophenecarboxylic acid | 3-[(4-tert-butylphenyl)methoxy]thiophene-2-carboxylic acid | 3-{[4-(tert-butyl)benzyl]oxy}-2-thiophenecarboxylic acid | MLS000755881 | SMR000337910 | cid_1483473
Type:
Small organic molecule
Emp. Form.:
C16H18O3S
Mol. Mass.:
290.377
SMILES:
CC(C)(C)c1ccc(COc2ccsc2C(O)=O)cc1
Structure:
Search PDB for entries with ligand similarity: