Reaction Details Report a problem with these data
Target
Beta-lactamase
Ligand
BDBM51995
Substrate
n/a
Meas. Tech.
FRET-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase.
IC50
59640±n/a nM
Citation
 PubChem, PC FRET-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase. PubChem Bioassay (2009)[AID] 
Target
Name:
Beta-lactamase
Synonyms:
Beta-lactamase | metallo-beta-lactamase IMP-1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27125.88
Organism:
Pseudomonas aeruginosa
Description:
gi_27368096
Residue:
246
Sequence:
MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN
  
Inhibitor
Name:
BDBM51995
Synonyms:
4-(phenylmethyl)-3-thiophen-2-yl-1H-1,2,4-triazole-5-thione | 4-benzyl-3-(2-thienyl)-1H-1,2,4-triazole-5-thione | 4-benzyl-3-thiophen-2-yl-1H-1,2,4-triazole-5-thione | MLS001006385 | SMR000349340 | cid_2383141
Type:
Small organic molecule
Emp. Form.:
C13H11N3S2
Mol. Mass.:
273.377
SMILES:
S=c1[nH]nc(-c2cccs2)n1Cc1ccccc1
Structure:
Search PDB for entries with ligand similarity: