Reaction Details Report a problem with these data
Target
POsterior Segregation
Ligand
BDBM52187
Substrate
n/a
Meas. Tech.
Fluorescent Polarization Homogeneous Dose Response HTS to Indentify Inhibitors of POS-1 Binding to mex-3-RNA
EC50
300000±n/a nM
Citation
 PubChem, PC Fluorescent Polarization Homogeneous Dose Response HTS to Indentify Inhibitors of POS-1 Binding to mex-3-RNA PubChem Bioassay (2009)[AID] 
Target
Name:
POsterior Segregation
Synonyms:
POsterior Segregation family member (pos-1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
29838.90
Organism:
Caenorhabditis elegans
Description:
gi_17562800
Residue:
264
Sequence:
MADNDFLSGEAIMVFKKEILDSHSDFTRSLSHQSASPEAYDQENVFSQDFQPFMKQDKETQNSASQPTSEQSLANRDPCTVPDDLREEMMRQRRKEDAFKTALCDAYKRSQACSYGDQCRFAHGVHELRLPMNPRGRNHPKYKTVLCDKFSMTGNCKYGTRCQFIHKIVDGNAAKLASGAHANTSSKSPARNAAAHNHSLFVPQGSTDRSMDLNQSLPIRQSDLVRAFARATRLDVSGYNSTAQLAQYFESQFQRIQQLSSHHH
  
Inhibitor
Name:
BDBM52187
Synonyms:
2-amino-1'-(3-methoxybenzyl)-2',5-dioxo-1',2',5,6,7,8-hexahydrospiro[chromene-4,3'-indole]-3-carbonitrile | 2-amino-1'-[(3-methoxyphenyl)methyl]-2',5-dioxo-3-spiro[7,8-dihydro-6H-1-benzopyran-4,3'-indole]carbonitrile | 2-amino-1'-[(3-methoxyphenyl)methyl]-2',5-dioxospiro[7,8-dihydro-6H-chromene-4,3'-indole]-3-carbonitrile | 2-amino-2',5-diketo-1'-m-anisyl-spiro[7,8-dihydro-6H-chromene-4,3'-indoline]-3-carbonitrile | 2-azanyl-1'-[(3-methoxyphenyl)methyl]-2',5-bis(oxidanylidene)spiro[7,8-dihydro-6H-chromene-4,3'-indole]-3-carbonitrile | MLS000050709 | SMR000078181 | cid_2962015
Type:
Small organic molecule
Emp. Form.:
C25H21N3O4
Mol. Mass.:
427.4519
SMILES:
COc1cccc(CN2C(=O)C3(C(C#N)C(=N)OC4=C3C(=O)CCC4)c3ccccc23)c1 |c:18|
Structure:
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