Reaction Details Report a problem with these data
Target
Dual specificity protein phosphatase 6
Ligand
BDBM53487
Substrate
n/a
Meas. Tech.
MKP-3 in vitro HTS assay
IC50
100000±n/a nM
Citation
 PubChem, PC MKP-3 in vitro HTS assay PubChem Bioassay (2009)[AID] 
Target
Name:
Dual specificity protein phosphatase 6
Synonyms:
DUS6_RAT | Dusp6 | MAP kinase phosphatase 3 | MKP-3 | Mitogen-activated protein kinase phosphatase 3 | Mkp3
Type:
Enzyme
Mol. Mass.:
42303.19
Organism:
Rattus norvegicus
Description:
gi_16758752
Residue:
381
Sequence:
MIDTLRPVPFASEMAISKTVAWLNEQLELGNEQLLLMDCRPQELYESSHIESAINVAIPGIMLRRLQKGNLPVRALFTRCEDRDRFTRRCGTDTVVLYDENSSDWNENTGGESVLGLLLKKLKDEGCRAFYLEGGFSKFQAEFALHCETNLDGSCSSSSPPLPVLGLGGLRISSDSSSDIESDLDRDPNSATDSDGSPLSNSQPSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLGLSSPCDNRVPAQQLYFTAPSNQNVYQVDSLQST
  
Inhibitor
Name:
BDBM53487
Synonyms:
2-(4-Fluoro-benzenesulfonylamino)-N-furan-2-ylmethyl-N-(phenethylcarbamoyl-methyl)-acetamide | 2-[(4-fluorophenyl)sulfonylamino]-N-(2-furanylmethyl)-N-[2-oxo-2-(2-phenylethylamino)ethyl]acetamide | 2-[(4-fluorophenyl)sulfonylamino]-N-(2-furfuryl)-N-[2-keto-2-(phenethylamino)ethyl]acetamide | 2-[(4-fluorophenyl)sulfonylamino]-N-(furan-2-ylmethyl)-N-[2-oxidanylidene-2-(2-phenylethylamino)ethyl]ethanamide | 2-[(4-fluorophenyl)sulfonylamino]-N-(furan-2-ylmethyl)-N-[2-oxo-2-(2-phenylethylamino)ethyl]acetamide | MLS000072217 | SMR000004767 | cid_653223
Type:
Small organic molecule
Emp. Form.:
C23H24FN3O5S
Mol. Mass.:
473.517
SMILES:
Fc1ccc(cc1)S(=O)(=O)NCC(=O)N(CC(=O)NCCc1ccccc1)Cc1ccco1
Structure:
Search PDB for entries with ligand similarity: