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Target
Dual specificity protein phosphatase 6
Ligand
BDBM35417
Substrate
n/a
Meas. Tech.
MKP-3 in vitro HTS assay
IC50
2500±n/a nM
Citation
 PubChem, PC MKP-3 in vitro HTS assay PubChem Bioassay (2009)[AID] 
Target
Name:
Dual specificity protein phosphatase 6
Synonyms:
DUS6_RAT | Dusp6 | MAP kinase phosphatase 3 | MKP-3 | Mitogen-activated protein kinase phosphatase 3 | Mkp3
Type:
Enzyme
Mol. Mass.:
42303.19
Organism:
Rattus norvegicus
Description:
gi_16758752
Residue:
381
Sequence:
MIDTLRPVPFASEMAISKTVAWLNEQLELGNEQLLLMDCRPQELYESSHIESAINVAIPGIMLRRLQKGNLPVRALFTRCEDRDRFTRRCGTDTVVLYDENSSDWNENTGGESVLGLLLKKLKDEGCRAFYLEGGFSKFQAEFALHCETNLDGSCSSSSPPLPVLGLGGLRISSDSSSDIESDLDRDPNSATDSDGSPLSNSQPSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLGLSSPCDNRVPAQQLYFTAPSNQNVYQVDSLQST
  
Inhibitor
Name:
BDBM35417
Synonyms:
MLS000089222 | N-[3-({[3-(1H-benzimidazol-2-yl)phenyl]amino}carbonyl)phenyl]-2-furamide | N-[3-[[3-(1H-benzimidazol-2-yl)anilino]-oxomethyl]phenyl]-2-furancarboxamide | N-[3-[[3-(1H-benzimidazol-2-yl)phenyl]carbamoyl]phenyl]-2-furamide | N-[3-[[3-(1H-benzimidazol-2-yl)phenyl]carbamoyl]phenyl]furan-2-carboxamide | SMR000072976 | cid_2192323
Type:
Small organic molecule
Emp. Form.:
C25H18N4O3
Mol. Mass.:
422.4354
SMILES:
O=C(Nc1cccc(c1)C(=O)Nc1cccc(c1)-c1nc2ccccc2[nH]1)c1ccco1
Structure:
Search PDB for entries with ligand similarity: