Reaction Details Report a problem with these data
Target
Dual specificity protein phosphatase 6
Ligand
BDBM35439
Substrate
n/a
Meas. Tech.
MKP-3 in vitro HTS assay
IC50
100000±n/a nM
Citation
 PubChem, PC MKP-3 in vitro HTS assay PubChem Bioassay (2009)[AID] 
Target
Name:
Dual specificity protein phosphatase 6
Synonyms:
DUS6_RAT | Dusp6 | MAP kinase phosphatase 3 | MKP-3 | Mitogen-activated protein kinase phosphatase 3 | Mkp3
Type:
Enzyme
Mol. Mass.:
42303.19
Organism:
Rattus norvegicus
Description:
gi_16758752
Residue:
381
Sequence:
MIDTLRPVPFASEMAISKTVAWLNEQLELGNEQLLLMDCRPQELYESSHIESAINVAIPGIMLRRLQKGNLPVRALFTRCEDRDRFTRRCGTDTVVLYDENSSDWNENTGGESVLGLLLKKLKDEGCRAFYLEGGFSKFQAEFALHCETNLDGSCSSSSPPLPVLGLGGLRISSDSSSDIESDLDRDPNSATDSDGSPLSNSQPSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLGLSSPCDNRVPAQQLYFTAPSNQNVYQVDSLQST
  
Inhibitor
Name:
BDBM35439
Synonyms:
(4-phenylphenyl)-[4-(2-pyridinylmethyl)-1-piperazinyl]methanone | (4-phenylphenyl)-[4-(2-pyridylmethyl)piperazino]methanone | (4-phenylphenyl)-[4-(pyridin-2-ylmethyl)piperazin-1-yl]methanone | MLS000108271 | SMR000104232 | cid_1148103
Type:
Small organic molecule
Emp. Form.:
C23H23N3O
Mol. Mass.:
357.4482
SMILES:
O=C(N1CCN(Cc2ccccn2)CC1)c1ccc(cc1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: