Reaction Details Report a problem with these data
Target
Dual specificity protein phosphatase 6
Ligand
BDBM48721
Substrate
n/a
Meas. Tech.
MKP-3 in vitro HTS assay
IC50
16200±n/a nM
Citation
 PubChem, PC MKP-3 in vitro HTS assay PubChem Bioassay (2009)[AID] 
Target
Name:
Dual specificity protein phosphatase 6
Synonyms:
DUS6_RAT | Dusp6 | MAP kinase phosphatase 3 | MKP-3 | Mitogen-activated protein kinase phosphatase 3 | Mkp3
Type:
Enzyme
Mol. Mass.:
42303.19
Organism:
Rattus norvegicus
Description:
gi_16758752
Residue:
381
Sequence:
MIDTLRPVPFASEMAISKTVAWLNEQLELGNEQLLLMDCRPQELYESSHIESAINVAIPGIMLRRLQKGNLPVRALFTRCEDRDRFTRRCGTDTVVLYDENSSDWNENTGGESVLGLLLKKLKDEGCRAFYLEGGFSKFQAEFALHCETNLDGSCSSSSPPLPVLGLGGLRISSDSSSDIESDLDRDPNSATDSDGSPLSNSQPSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLGLSSPCDNRVPAQQLYFTAPSNQNVYQVDSLQST
  
Inhibitor
Name:
BDBM48721
Synonyms:
1-(3,4-Dichloro-phenyl)-3-(5-pyridin-4-yl-[1,3,4]thiadiazol-2-yl)-urea | 1-(3,4-dichlorophenyl)-3-(5-pyridin-4-yl-1,3,4-thiadiazol-2-yl)urea | 1-(3,4-dichlorophenyl)-3-[5-(4-pyridyl)-1,3,4-thiadiazol-2-yl]urea | MLS000559245 | SMR000178207 | cid_1075698
Type:
Small organic molecule
Emp. Form.:
C14H9Cl2N5OS
Mol. Mass.:
366.225
SMILES:
Clc1ccc(NC(=O)Nc2nnc(s2)-c2ccncc2)cc1Cl
Structure:
Search PDB for entries with ligand similarity: