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Target
Tyrosine-protein phosphatase non-receptor type 7
Ligand
BDBM34164
Substrate
n/a
Meas. Tech.
HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target
IC50
2180±n/a nM
Citation
 PubChem, PC HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target PubChem Bioassay (2008)[AID] 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 7
Synonyms:
He-PTP | Hematopoietic protein-tyrosine phosphatase | Hematopoietic protein-tyrosine phosphatase (HEPTP) | PTN7_HUMAN | PTPN7 | Protein-tyrosine phosphatase LC-PTP | Tyrosine-protein phosphatase non-receptor type 7 | Tyrosine-protein phosphatase non-receptor type 7 (HEPTP)
Type:
Protein
Mol. Mass.:
40530.79
Organism:
Homo sapiens (Human)
Description:
P35236
Residue:
360
Sequence:
MVQAHGGRSRAQPLTLSLGAAMTQPPPEKTPAKKHVRLQERRGSNVALMLDVRSLGAVEPICSVNTPREVTLHFLRTAGHPLTRWALQRQPPSPKQLEEEFLKIPSNFVSPEDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGKEKCVHYWPTEEETYGPFQIRIQDMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAGQLPEEPSP
  
Inhibitor
Name:
BDBM34164
Synonyms:
(3E)-3-[5-(4-fluorophenyl)-1,2,4-oxadiazol-3-ylidene]-6-methoxy-2-quinolinone | (3E)-3-[5-(4-fluorophenyl)-1,2,4-oxadiazol-3-ylidene]-6-methoxy-carbostyril | (3E)-3-[5-(4-fluorophenyl)-1,2,4-oxadiazol-3-ylidene]-6-methoxy-quinolin-2-one | (3E)-3-[5-(4-fluorophenyl)-1,2,4-oxadiazol-3-ylidene]-6-methoxyquinolin-2-one | 3-[5-(4-Fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-6-methoxy-quinolin-2-ol | MLS000071054 | SMR000015028 | cid_5423532
Type:
Small organic molecule
Emp. Form.:
C18H12FN3O3
Mol. Mass.:
337.3046
SMILES:
COc1ccc2[nH]c(=O)c(cc2c1)-c1noc(n1)-c1ccc(F)cc1
Structure:
Search PDB for entries with ligand similarity: