Reaction Details Report a problem with these data
Target
Tyrosine-protein phosphatase non-receptor type 7
Ligand
BDBM53507
Substrate
n/a
Meas. Tech.
HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target
IC50
100000±n/a nM
Citation
 PubChem, PC HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target PubChem Bioassay (2008)[AID] 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 7
Synonyms:
He-PTP | Hematopoietic protein-tyrosine phosphatase | Hematopoietic protein-tyrosine phosphatase (HEPTP) | PTN7_HUMAN | PTPN7 | Protein-tyrosine phosphatase LC-PTP | Tyrosine-protein phosphatase non-receptor type 7 | Tyrosine-protein phosphatase non-receptor type 7 (HEPTP)
Type:
Protein
Mol. Mass.:
40530.79
Organism:
Homo sapiens (Human)
Description:
P35236
Residue:
360
Sequence:
MVQAHGGRSRAQPLTLSLGAAMTQPPPEKTPAKKHVRLQERRGSNVALMLDVRSLGAVEPICSVNTPREVTLHFLRTAGHPLTRWALQRQPPSPKQLEEEFLKIPSNFVSPEDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGKEKCVHYWPTEEETYGPFQIRIQDMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAGQLPEEPSP
  
Inhibitor
Name:
BDBM53507
Synonyms:
2-thiophenecarboxylic acid [1-(2-furanylmethylamino)-3-methyl-1-oxobutan-2-yl] ester | MLS000074331 | SMR000006570 | Thiophene-2-carboxylic acid 1-[(furan-2-ylmethyl)-carbamoyl]-2-methyl-propyl ester | [1-(furan-2-ylmethylamino)-3-methyl-1-oxidanylidene-butan-2-yl] thiophene-2-carboxylate | [1-(furan-2-ylmethylamino)-3-methyl-1-oxobutan-2-yl] thiophene-2-carboxylate | cid_652392 | thiophene-2-carboxylic acid [1-(2-furfurylcarbamoyl)-2-methyl-propyl] ester
Type:
Small organic molecule
Emp. Form.:
C15H17NO4S
Mol. Mass.:
307.365
SMILES:
CC(C)C(OC(=O)c1cccs1)C(=O)NCc1ccco1
Structure:
Search PDB for entries with ligand similarity: