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Target
Tyrosine-protein phosphatase non-receptor type 7
Ligand
BDBM53510
Substrate
n/a
Meas. Tech.
HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target
IC50
100000±n/a nM
Citation
 PubChem, PC HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target PubChem Bioassay (2008)[AID] 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 7
Synonyms:
He-PTP | Hematopoietic protein-tyrosine phosphatase | Hematopoietic protein-tyrosine phosphatase (HEPTP) | PTN7_HUMAN | PTPN7 | Protein-tyrosine phosphatase LC-PTP | Tyrosine-protein phosphatase non-receptor type 7 | Tyrosine-protein phosphatase non-receptor type 7 (HEPTP)
Type:
Protein
Mol. Mass.:
40530.79
Organism:
Homo sapiens (Human)
Description:
P35236
Residue:
360
Sequence:
MVQAHGGRSRAQPLTLSLGAAMTQPPPEKTPAKKHVRLQERRGSNVALMLDVRSLGAVEPICSVNTPREVTLHFLRTAGHPLTRWALQRQPPSPKQLEEEFLKIPSNFVSPEDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGKEKCVHYWPTEEETYGPFQIRIQDMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAGQLPEEPSP
  
Inhibitor
Name:
BDBM53510
Synonyms:
MLS000073728 | N-(5-Ethyl-[1,3,4]thiadiazol-2-yl)-2-[4-isobutyl-5-(2-methyl-furan-3-yl)-4H-[1,2,4]triazol-3-ylsulfanyl]-acetamide | N-(5-ethyl-1,3,4-thiadiazol-2-yl)-2-[[4-isobutyl-5-(2-methyl-3-furyl)-1,2,4-triazol-3-yl]thio]acetamide | N-(5-ethyl-1,3,4-thiadiazol-2-yl)-2-[[5-(2-methyl-3-furanyl)-4-(2-methylpropyl)-1,2,4-triazol-3-yl]thio]acetamide | N-(5-ethyl-1,3,4-thiadiazol-2-yl)-2-[[5-(2-methylfuran-3-yl)-4-(2-methylpropyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide | N-(5-ethyl-1,3,4-thiadiazol-2-yl)-2-[[5-(2-methylfuran-3-yl)-4-(2-methylpropyl)-1,2,4-triazol-3-yl]sulfanyl]ethanamide | SMR000005711 | cid_655910
Type:
Small organic molecule
Emp. Form.:
C17H22N6O2S2
Mol. Mass.:
406.526
SMILES:
CCc1nnc(NC(=O)CSc2nnc(-c3ccoc3C)n2CC(C)C)s1
Structure:
Search PDB for entries with ligand similarity: