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Target
Tyrosine-protein phosphatase non-receptor type 7
Ligand
BDBM53519
Substrate
n/a
Meas. Tech.
HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target
IC50
100000±n/a nM
Citation
 PubChem, PC HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target PubChem Bioassay (2008)[AID] 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 7
Synonyms:
He-PTP | Hematopoietic protein-tyrosine phosphatase | Hematopoietic protein-tyrosine phosphatase (HEPTP) | PTN7_HUMAN | PTPN7 | Protein-tyrosine phosphatase LC-PTP | Tyrosine-protein phosphatase non-receptor type 7 | Tyrosine-protein phosphatase non-receptor type 7 (HEPTP)
Type:
Protein
Mol. Mass.:
40530.79
Organism:
Homo sapiens (Human)
Description:
P35236
Residue:
360
Sequence:
MVQAHGGRSRAQPLTLSLGAAMTQPPPEKTPAKKHVRLQERRGSNVALMLDVRSLGAVEPICSVNTPREVTLHFLRTAGHPLTRWALQRQPPSPKQLEEEFLKIPSNFVSPEDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGKEKCVHYWPTEEETYGPFQIRIQDMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAGQLPEEPSP
  
Inhibitor
Name:
BDBM53519
Synonyms:
(6E)-4-chloranyl-6-[4-(4-methylphenyl)carbonyl-1,2-dihydropyrazol-3-ylidene]cyclohexa-2,4-dien-1-one | (6E)-4-chloro-6-(4-p-toluoyl-3-pyrazolin-3-ylidene)cyclohexa-2,4-dien-1-one | (6E)-4-chloro-6-[4-(4-methylbenzoyl)-1,2-dihydropyrazol-3-ylidene]cyclohexa-2,4-dien-1-one | (6E)-4-chloro-6-[4-[(4-methylphenyl)-oxomethyl]-1,2-dihydropyrazol-3-ylidene]-1-cyclohexa-2,4-dienone | MLS000038841 | SMR000057870 | cid_5389205
Type:
Small organic molecule
Emp. Form.:
C17H13ClN2O2
Mol. Mass.:
312.75
SMILES:
Cc1ccc(cc1)C(=O)c1c[nH]nc1-c1cc(Cl)ccc1O
Structure:
Search PDB for entries with ligand similarity: