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Target
Tyrosine-protein phosphatase non-receptor type 7
Ligand
BDBM53534
Substrate
n/a
Meas. Tech.
HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target
IC50
100000±n/a nM
Citation
 PubChem, PC HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target PubChem Bioassay (2008)[AID] 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 7
Synonyms:
He-PTP | Hematopoietic protein-tyrosine phosphatase | Hematopoietic protein-tyrosine phosphatase (HEPTP) | PTN7_HUMAN | PTPN7 | Protein-tyrosine phosphatase LC-PTP | Tyrosine-protein phosphatase non-receptor type 7 | Tyrosine-protein phosphatase non-receptor type 7 (HEPTP)
Type:
Protein
Mol. Mass.:
40530.79
Organism:
Homo sapiens (Human)
Description:
P35236
Residue:
360
Sequence:
MVQAHGGRSRAQPLTLSLGAAMTQPPPEKTPAKKHVRLQERRGSNVALMLDVRSLGAVEPICSVNTPREVTLHFLRTAGHPLTRWALQRQPPSPKQLEEEFLKIPSNFVSPEDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGKEKCVHYWPTEEETYGPFQIRIQDMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAGQLPEEPSP
  
Inhibitor
Name:
BDBM53534
Synonyms:
MLS000054998 | SMR000065805 | [5-(6-benzamidopurin-9-yl)-3-fluoranyl-4-oxidanyl-oxolan-2-yl]methyl benzoate | [5-(6-benzamidopurin-9-yl)-3-fluoro-4-hydroxyoxolan-2-yl]methyl benzoate | benzoic acid [5-(6-benzamido-9-purinyl)-3-fluoro-4-hydroxy-2-oxolanyl]methyl ester | benzoic acid [5-(6-benzamidopurin-9-yl)-3-fluoro-4-hydroxy-tetrahydrofuran-2-yl]methyl ester | cid_2999063
Type:
Small organic molecule
Emp. Form.:
C24H20FN5O5
Mol. Mass.:
477.4445
SMILES:
OC1C(F)C(COC(=O)c2ccccc2)OC1n1cnc2c(NC(=O)c3ccccc3)ncnc12
Structure:
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