Reaction Details Report a problem with these data
Target
Tyrosine-protein phosphatase non-receptor type 7
Ligand
BDBM53537
Substrate
n/a
Meas. Tech.
HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target
IC50
100000±n/a nM
Citation
 PubChem, PC HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target PubChem Bioassay (2008)[AID] 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 7
Synonyms:
He-PTP | Hematopoietic protein-tyrosine phosphatase | Hematopoietic protein-tyrosine phosphatase (HEPTP) | PTN7_HUMAN | PTPN7 | Protein-tyrosine phosphatase LC-PTP | Tyrosine-protein phosphatase non-receptor type 7 | Tyrosine-protein phosphatase non-receptor type 7 (HEPTP)
Type:
Protein
Mol. Mass.:
40530.79
Organism:
Homo sapiens (Human)
Description:
P35236
Residue:
360
Sequence:
MVQAHGGRSRAQPLTLSLGAAMTQPPPEKTPAKKHVRLQERRGSNVALMLDVRSLGAVEPICSVNTPREVTLHFLRTAGHPLTRWALQRQPPSPKQLEEEFLKIPSNFVSPEDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGKEKCVHYWPTEEETYGPFQIRIQDMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAGQLPEEPSP
  
Inhibitor
Name:
BDBM53537
Synonyms:
(6E)-6-[4-(1-benzofuran-2-yl)-5-(trifluoromethyl)-1,2-dihydropyrazol-3-ylidene]-3-methoxy-cyclohexa-2,4-dien-1-one | (6E)-6-[4-(1-benzofuran-2-yl)-5-(trifluoromethyl)-1,2-dihydropyrazol-3-ylidene]-3-methoxycyclohexa-2,4-dien-1-one | (6E)-6-[4-(2-benzofuranyl)-5-(trifluoromethyl)-1,2-dihydropyrazol-3-ylidene]-3-methoxy-1-cyclohexa-2,4-dienone | (6E)-6-[4-(benzofuran-2-yl)-5-(trifluoromethyl)-3-pyrazolin-3-ylidene]-3-methoxy-cyclohexa-2,4-dien-1-one | MLS000097992 | SMR000060635 | cid_5742541
Type:
Small organic molecule
Emp. Form.:
C19H13F3N2O3
Mol. Mass.:
374.3133
SMILES:
COc1ccc(-c2n[nH]c(c2-c2cc3ccccc3o2)C(F)(F)F)c(O)c1
Structure:
Search PDB for entries with ligand similarity: