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Target
Tyrosine-protein phosphatase non-receptor type 7
Ligand
BDBM45388
Substrate
n/a
Meas. Tech.
HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target
IC50
100000±n/a nM
Citation
 PubChem, PC HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target PubChem Bioassay (2008)[AID] 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 7
Synonyms:
He-PTP | Hematopoietic protein-tyrosine phosphatase | Hematopoietic protein-tyrosine phosphatase (HEPTP) | PTN7_HUMAN | PTPN7 | Protein-tyrosine phosphatase LC-PTP | Tyrosine-protein phosphatase non-receptor type 7 | Tyrosine-protein phosphatase non-receptor type 7 (HEPTP)
Type:
Protein
Mol. Mass.:
40530.79
Organism:
Homo sapiens (Human)
Description:
P35236
Residue:
360
Sequence:
MVQAHGGRSRAQPLTLSLGAAMTQPPPEKTPAKKHVRLQERRGSNVALMLDVRSLGAVEPICSVNTPREVTLHFLRTAGHPLTRWALQRQPPSPKQLEEEFLKIPSNFVSPEDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGKEKCVHYWPTEEETYGPFQIRIQDMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAGQLPEEPSP
  
Inhibitor
Name:
BDBM45388
Synonyms:
MLS000097240 | N-(4-chlorobenzyl)-4-methyl-1H-pyrazole-1-carbothioamide | N-(4-chlorobenzyl)-4-methyl-pyrazole-1-carbothioamide | N-[(4-chlorophenyl)methyl]-4-methyl-1-pyrazolecarbothioamide | N-[(4-chlorophenyl)methyl]-4-methyl-pyrazole-1-carbothioamide | N-[(4-chlorophenyl)methyl]-4-methylpyrazole-1-carbothioamide | SMR000076862 | cid_970944
Type:
Small organic molecule
Emp. Form.:
C12H12ClN3S
Mol. Mass.:
265.762
SMILES:
Cc1cnn(c1)C(=S)NCc1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: