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Target
Tyrosine-protein phosphatase non-receptor type 7
Ligand
BDBM53566
Substrate
n/a
Meas. Tech.
HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target
IC50
100000±n/a nM
Citation
 PubChem, PC HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target PubChem Bioassay (2008)[AID] 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 7
Synonyms:
He-PTP | Hematopoietic protein-tyrosine phosphatase | Hematopoietic protein-tyrosine phosphatase (HEPTP) | PTN7_HUMAN | PTPN7 | Protein-tyrosine phosphatase LC-PTP | Tyrosine-protein phosphatase non-receptor type 7 | Tyrosine-protein phosphatase non-receptor type 7 (HEPTP)
Type:
Protein
Mol. Mass.:
40530.79
Organism:
Homo sapiens (Human)
Description:
P35236
Residue:
360
Sequence:
MVQAHGGRSRAQPLTLSLGAAMTQPPPEKTPAKKHVRLQERRGSNVALMLDVRSLGAVEPICSVNTPREVTLHFLRTAGHPLTRWALQRQPPSPKQLEEEFLKIPSNFVSPEDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGKEKCVHYWPTEEETYGPFQIRIQDMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAGQLPEEPSP
  
Inhibitor
Name:
BDBM53566
Synonyms:
3-(4-morpholinylsulfonyl)-4-(2-oxolanylmethylamino)-N-phenylbenzamide | 3-(4-morpholinylsulfonyl)-N-phenyl-4-[(tetrahydro-2-furanylmethyl)amino]benzamide | 3-morpholin-4-ylsulfonyl-4-(oxolan-2-ylmethylamino)-N-phenyl-benzamide | 3-morpholin-4-ylsulfonyl-4-(oxolan-2-ylmethylamino)-N-phenylbenzamide | 3-morpholinosulfonyl-N-phenyl-4-(tetrahydrofurfurylamino)benzamide | MLS000050465 | SMR000076371 | cid_2953795
Type:
Small organic molecule
Emp. Form.:
C22H27N3O5S
Mol. Mass.:
445.532
SMILES:
O=C(Nc1ccccc1)c1ccc(NCC2CCCO2)c(c1)S(=O)(=O)N1CCOCC1
Structure:
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