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Target
Tyrosine-protein phosphatase non-receptor type 7
Ligand
BDBM34550
Substrate
n/a
Meas. Tech.
HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target
IC50
4150±n/a nM
Citation
 PubChem, PC HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target PubChem Bioassay (2008)[AID] 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 7
Synonyms:
He-PTP | Hematopoietic protein-tyrosine phosphatase | Hematopoietic protein-tyrosine phosphatase (HEPTP) | PTN7_HUMAN | PTPN7 | Protein-tyrosine phosphatase LC-PTP | Tyrosine-protein phosphatase non-receptor type 7 | Tyrosine-protein phosphatase non-receptor type 7 (HEPTP)
Type:
Protein
Mol. Mass.:
40530.79
Organism:
Homo sapiens (Human)
Description:
P35236
Residue:
360
Sequence:
MVQAHGGRSRAQPLTLSLGAAMTQPPPEKTPAKKHVRLQERRGSNVALMLDVRSLGAVEPICSVNTPREVTLHFLRTAGHPLTRWALQRQPPSPKQLEEEFLKIPSNFVSPEDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGKEKCVHYWPTEEETYGPFQIRIQDMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAGQLPEEPSP
  
Inhibitor
Name:
BDBM34550
Synonyms:
MLS000104887 | N-(2-furanylmethyl)-3-[[3-(2-furanylmethylamino)-3-oxopropyl]thio]propanamide | N-(2-furfuryl)-3-[[3-(2-furfurylamino)-3-keto-propyl]thio]propionamide | N-(furan-2-ylmethyl)-3-[3-(furan-2-ylmethylamino)-3-oxidanylidene-propyl]sulfanyl-propanamide | N-(furan-2-ylmethyl)-3-[3-(furan-2-ylmethylamino)-3-oxopropyl]sulfanylpropanamide | SMR000054818 | cid_557197
Type:
Small organic molecule
Emp. Form.:
C16H20N2O4S
Mol. Mass.:
336.406
SMILES:
O=C(CCSCCC(=O)NCc1ccco1)NCc1ccco1
Structure:
Search PDB for entries with ligand similarity: