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Target
Mannose-6-phosphate isomerase
Ligand
BDBM34568
Substrate
n/a
Meas. Tech.
HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay.
IC50
50000±n/a nM
Citation
 PubChem, PC HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay. PubChem Bioassay (2009)[AID] 
Target
Name:
Mannose-6-phosphate isomerase
Synonyms:
MPI | MPI protein | MPI_HUMAN | Mannose-6-phosphate isomerase | PMI1
Type:
PROTEIN
Mol. Mass.:
46651.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448919
Residue:
423
Sequence:
MAAPRVFPLSCAVQQYAWGKMGSNSEVARLLASSDPLAQIAEDKPYAELWMGTHPRGDAKILDNRISQKTLSQWIAENQDSLGSKVKDTFNGNLPFLFKVLSVETPLSIQAHPNKELAEKLHLQAPQHYPDANHKPEMAIALTPFQGLCGFRPVEEIVTFLKKVPEFQFLIGDEAATHLKQTMSHDSQAVASSLQSCFSHLMKSEKKVVVEQLNLLVKRISQQAAAGNNMEDIFGELLLQLHQQYPGDIGCFAIYFLNLLTLKPGEAMFLEANVPHAYLKGDCVECMACSDNTVRAGLTPKFIDVPTLCEMLSYTPSSSKDRLFLPTRSQEDPYLSIYDPPVPDFTIMKTEVPGSVTEYKVLALDSASILLMVQGTVIASTPTTQTPIPLQRGGVLFIGANESVSLKLTEPKDLLIFRACCLL
  
Inhibitor
Name:
BDBM34568
Synonyms:
3-(2-hydroxyethylamino)-7-(phenylmethyl)-1-[(phenylmethyl)amino]-6,8-dihydro-5H-2,7-naphthyridine-4-carbonitrile | 7-Benzyl-1-benzylamino-3-(2-hydroxy-ethylamino)-5,6,7,8-tetrahydro-[2,7]naphthyridine-4-carbonitrile | 7-benzyl-1-(benzylamino)-3-(2-hydroxyethylamino)-6,8-dihydro-5H-2,7-naphthyridine-4-carbonitrile | MLS000031793 | SMR000008652 | cid_651319
Type:
Small organic molecule
Emp. Form.:
C25H27N5O
Mol. Mass.:
413.5148
SMILES:
OCCNc1nc(NCc2ccccc2)c2CN(Cc3ccccc3)CCc2c1C#N
Structure:
Search PDB for entries with ligand similarity: