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Target
Mannose-6-phosphate isomerase
Ligand
BDBM34580
Substrate
n/a
Meas. Tech.
HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay.
IC50
16378±n/a nM
Citation
 PubChem, PC HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay. PubChem Bioassay (2009)[AID] 
Target
Name:
Mannose-6-phosphate isomerase
Synonyms:
MPI | MPI protein | MPI_HUMAN | Mannose-6-phosphate isomerase | PMI1
Type:
PROTEIN
Mol. Mass.:
46651.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448919
Residue:
423
Sequence:
MAAPRVFPLSCAVQQYAWGKMGSNSEVARLLASSDPLAQIAEDKPYAELWMGTHPRGDAKILDNRISQKTLSQWIAENQDSLGSKVKDTFNGNLPFLFKVLSVETPLSIQAHPNKELAEKLHLQAPQHYPDANHKPEMAIALTPFQGLCGFRPVEEIVTFLKKVPEFQFLIGDEAATHLKQTMSHDSQAVASSLQSCFSHLMKSEKKVVVEQLNLLVKRISQQAAAGNNMEDIFGELLLQLHQQYPGDIGCFAIYFLNLLTLKPGEAMFLEANVPHAYLKGDCVECMACSDNTVRAGLTPKFIDVPTLCEMLSYTPSSSKDRLFLPTRSQEDPYLSIYDPPVPDFTIMKTEVPGSVTEYKVLALDSASILLMVQGTVIASTPTTQTPIPLQRGGVLFIGANESVSLKLTEPKDLLIFRACCLL
  
Inhibitor
Name:
BDBM34580
Synonyms:
(2Z)-2-[[hydroxy(methyl)amino]methylene]quinolin-8-one | (2Z)-2-[[hydroxy(methyl)amino]methylidene]-8-quinolinone | (2Z)-2-[[hydroxy(methyl)amino]methylidene]quinolin-8-one | (2Z)-2-[[methyl(oxidanyl)amino]methylidene]quinolin-8-one | MLS000037739 | SMR000041778 | cid_5389291
Type:
Small organic molecule
Emp. Form.:
C11H10N2O2
Mol. Mass.:
202.2093
SMILES:
CN(O)\C=c1\ccc2=CC=CC(=O)c2n1 |c:9,t:7|
Structure:
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