Reaction Details Report a problem with these data
Target
Mannose-6-phosphate isomerase
Ligand
BDBM34589
Substrate
n/a
Meas. Tech.
HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay.
IC50
50000±n/a nM
Citation
 PubChem, PC HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay. PubChem Bioassay (2009)[AID] 
Target
Name:
Mannose-6-phosphate isomerase
Synonyms:
MPI | MPI protein | MPI_HUMAN | Mannose-6-phosphate isomerase | PMI1
Type:
PROTEIN
Mol. Mass.:
46651.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448919
Residue:
423
Sequence:
MAAPRVFPLSCAVQQYAWGKMGSNSEVARLLASSDPLAQIAEDKPYAELWMGTHPRGDAKILDNRISQKTLSQWIAENQDSLGSKVKDTFNGNLPFLFKVLSVETPLSIQAHPNKELAEKLHLQAPQHYPDANHKPEMAIALTPFQGLCGFRPVEEIVTFLKKVPEFQFLIGDEAATHLKQTMSHDSQAVASSLQSCFSHLMKSEKKVVVEQLNLLVKRISQQAAAGNNMEDIFGELLLQLHQQYPGDIGCFAIYFLNLLTLKPGEAMFLEANVPHAYLKGDCVECMACSDNTVRAGLTPKFIDVPTLCEMLSYTPSSSKDRLFLPTRSQEDPYLSIYDPPVPDFTIMKTEVPGSVTEYKVLALDSASILLMVQGTVIASTPTTQTPIPLQRGGVLFIGANESVSLKLTEPKDLLIFRACCLL
  
Inhibitor
Name:
BDBM34589
Synonyms:
1,8-bis(azanyl)-6-ethoxy-3-morpholin-4-yl-2,7-naphthyridine-4-carbonitrile | 1,8-diamino-6-ethoxy-3-(4-morpholinyl)-2,7-naphthyridine-4-carbonitrile | 1,8-diamino-6-ethoxy-3-morpholin-4-yl-2,7-naphthyridine-4-carbonitrile | 1,8-diamino-6-ethoxy-3-morpholino-2,7-naphthyridine-4-carbonitrile | MLS000055261 | SMR000061745 | cid_728280
Type:
Small organic molecule
Emp. Form.:
C15H18N6O2
Mol. Mass.:
314.3424
SMILES:
CCOc1cc2c(C#N)c(nc(N)c2c(N)n1)N1CCOCC1
Structure:
Search PDB for entries with ligand similarity: