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Target
Mannose-6-phosphate isomerase
Ligand
BDBM34674
Substrate
n/a
Meas. Tech.
HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay.
IC50
50000±n/a nM
Citation
 PubChem, PC HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay. PubChem Bioassay (2009)[AID] 
Target
Name:
Mannose-6-phosphate isomerase
Synonyms:
MPI | MPI protein | MPI_HUMAN | Mannose-6-phosphate isomerase | PMI1
Type:
PROTEIN
Mol. Mass.:
46651.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448919
Residue:
423
Sequence:
MAAPRVFPLSCAVQQYAWGKMGSNSEVARLLASSDPLAQIAEDKPYAELWMGTHPRGDAKILDNRISQKTLSQWIAENQDSLGSKVKDTFNGNLPFLFKVLSVETPLSIQAHPNKELAEKLHLQAPQHYPDANHKPEMAIALTPFQGLCGFRPVEEIVTFLKKVPEFQFLIGDEAATHLKQTMSHDSQAVASSLQSCFSHLMKSEKKVVVEQLNLLVKRISQQAAAGNNMEDIFGELLLQLHQQYPGDIGCFAIYFLNLLTLKPGEAMFLEANVPHAYLKGDCVECMACSDNTVRAGLTPKFIDVPTLCEMLSYTPSSSKDRLFLPTRSQEDPYLSIYDPPVPDFTIMKTEVPGSVTEYKVLALDSASILLMVQGTVIASTPTTQTPIPLQRGGVLFIGANESVSLKLTEPKDLLIFRACCLL
  
Inhibitor
Name:
BDBM34674
Synonyms:
3-(2-methylphenyl)-5-indeno[1,2-c]pyridazinone | 3-(2-methylphenyl)-5H-indeno[1,2-c]pyridazin-5-one | 3-(2-methylphenyl)indeno[1,2-c]pyridazin-5-one | 3-(o-tolyl)indeno[1,2-c]pyridazin-5-one | 3-o-Tolyl-indeno[1,2-c]pyridazin-5-one | 3-o-tolyl-5H-indeno[1,2-c]pyridazin-5-one | CHEMBL339561 | MLS000541539 | SMR000126397 | cid_2769183
Type:
Small organic molecule
Emp. Form.:
C18H12N2O
Mol. Mass.:
272.3007
SMILES:
Cc1ccccc1-c1cc2C(=O)c3ccccc3-c2nn1
Structure:
Search PDB for entries with ligand similarity: