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Target
Mannose-6-phosphate isomerase
Ligand
BDBM53606
Substrate
n/a
Meas. Tech.
HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay.
IC50
50000±n/a nM
Citation
 PubChem, PC HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay. PubChem Bioassay (2009)[AID] 
Target
Name:
Mannose-6-phosphate isomerase
Synonyms:
MPI | MPI protein | MPI_HUMAN | Mannose-6-phosphate isomerase | PMI1
Type:
PROTEIN
Mol. Mass.:
46651.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448919
Residue:
423
Sequence:
MAAPRVFPLSCAVQQYAWGKMGSNSEVARLLASSDPLAQIAEDKPYAELWMGTHPRGDAKILDNRISQKTLSQWIAENQDSLGSKVKDTFNGNLPFLFKVLSVETPLSIQAHPNKELAEKLHLQAPQHYPDANHKPEMAIALTPFQGLCGFRPVEEIVTFLKKVPEFQFLIGDEAATHLKQTMSHDSQAVASSLQSCFSHLMKSEKKVVVEQLNLLVKRISQQAAAGNNMEDIFGELLLQLHQQYPGDIGCFAIYFLNLLTLKPGEAMFLEANVPHAYLKGDCVECMACSDNTVRAGLTPKFIDVPTLCEMLSYTPSSSKDRLFLPTRSQEDPYLSIYDPPVPDFTIMKTEVPGSVTEYKVLALDSASILLMVQGTVIASTPTTQTPIPLQRGGVLFIGANESVSLKLTEPKDLLIFRACCLL
  
Inhibitor
Name:
BDBM53606
Synonyms:
(E)-2-cyano-N-phenyl-3-(3-pyridinyl)-2-propenamide | (E)-2-cyano-N-phenyl-3-(3-pyridyl)acrylamide | (E)-2-cyano-N-phenyl-3-pyridin-3-yl-prop-2-enamide | (E)-2-cyano-N-phenyl-3-pyridin-3-ylprop-2-enamide | 2-Cyano-N-phenyl-3-pyridin-3-yl-acrylamide | MLS000562306 | SMR000176579 | cid_775040
Type:
Small organic molecule
Emp. Form.:
C15H11N3O
Mol. Mass.:
249.2673
SMILES:
O=C(Nc1ccccc1)C(=C\c1cccnc1)\C#N
Structure:
Search PDB for entries with ligand similarity: