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Target
Mannose-6-phosphate isomerase
Ligand
BDBM46609
Substrate
n/a
Meas. Tech.
HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay.
IC50
12667±n/a nM
Citation
 PubChem, PC HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay. PubChem Bioassay (2009)[AID] 
Target
Name:
Mannose-6-phosphate isomerase
Synonyms:
MPI | MPI protein | MPI_HUMAN | Mannose-6-phosphate isomerase | PMI1
Type:
PROTEIN
Mol. Mass.:
46651.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448919
Residue:
423
Sequence:
MAAPRVFPLSCAVQQYAWGKMGSNSEVARLLASSDPLAQIAEDKPYAELWMGTHPRGDAKILDNRISQKTLSQWIAENQDSLGSKVKDTFNGNLPFLFKVLSVETPLSIQAHPNKELAEKLHLQAPQHYPDANHKPEMAIALTPFQGLCGFRPVEEIVTFLKKVPEFQFLIGDEAATHLKQTMSHDSQAVASSLQSCFSHLMKSEKKVVVEQLNLLVKRISQQAAAGNNMEDIFGELLLQLHQQYPGDIGCFAIYFLNLLTLKPGEAMFLEANVPHAYLKGDCVECMACSDNTVRAGLTPKFIDVPTLCEMLSYTPSSSKDRLFLPTRSQEDPYLSIYDPPVPDFTIMKTEVPGSVTEYKVLALDSASILLMVQGTVIASTPTTQTPIPLQRGGVLFIGANESVSLKLTEPKDLLIFRACCLL
  
Inhibitor
Name:
BDBM46609
Synonyms:
1,3-bis(1H-1,2,4-triazol-5-ylsulfanyl)propan-2-one | 1,3-bis(1H-1,2,4-triazol-5-ylthio)-2-propanone | 1,3-bis(1H-1,2,4-triazol-5-ylthio)acetone | MLS-0238694.0001 | cid_1625367
Type:
Small organic molecule
Emp. Form.:
C7H8N6OS2
Mol. Mass.:
256.308
SMILES:
O=C(CSc1nnc[nH]1)CSc1nnc[nH]1
Structure:
Search PDB for entries with ligand similarity: