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Target
SUMO-conjugating enzyme UBC9
Ligand
BDBM31750
Substrate
n/a
Meas. Tech.
AlphaScreen confirmatory assay for validation of inhibitors of SUMOylation
IC50
2910±n/a nM
Citation
PubChem, PC AlphaScreen confirmatory assay for validation of inhibitors of SUMOylation PubChem Bioassay (2010)[AID]
More Info.:
Target
Name:
SUMO-conjugating enzyme UBC9
Synonyms:
UBC9 | UBC9_HUMAN | UBCE9 | UBE2I | ubiquitin-conjugating enzyme E2I
Type:
Enzyme Catalytic Domain
Mol. Mass.:
18011.66
Organism:
Homo sapiens (Human)
Description:
gi_4507785
Residue:
158
Sequence:
MSGIALSRLAQERKAWRKDHPFGFVAVPTKNPDGTMNLMNWECAIPGKKGTPWEGGLFKLRMLFKDDYPSSPPKCKFEPPLFHPNVYPSGTVCLSILEEDKDWRPAITIKQILLGIQELLNEPNIQDPAQAEAYTIYCQNRVEYEKRVRAQAKKFAPS
Inhibitor
Name:
BDBM31750
Synonyms:
5,6-bis(2-furanyl)-3-(methylthio)-1,2,4-triazine | 5,6-bis(2-furyl)-3-(methylthio)-1,2,4-triazine | 5,6-bis(furan-2-yl)-3-methylsulfanyl-1,2,4-triazine | MLS-0012454.0001 | cid_3053058
Type:
Small organic molecule
Emp. Form.:
C12H9N3O2S
Mol. Mass.:
259.284
SMILES:
CSc1nnc(-c2ccco2)c(n1)-c1ccco1