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Target
SUMO-conjugating enzyme UBC9
Ligand
BDBM61235
Substrate
n/a
Meas. Tech.
AlphaScreen confirmatory assay for validation of inhibitors of SUMOylation
IC50
29910±n/a nM
Citation
 PubChem, PC AlphaScreen confirmatory assay for validation of inhibitors of SUMOylation PubChem Bioassay (2010)[AID] 
Target
Name:
SUMO-conjugating enzyme UBC9
Synonyms:
UBC9 | UBC9_HUMAN | UBCE9 | UBE2I | ubiquitin-conjugating enzyme E2I
Type:
Enzyme Catalytic Domain
Mol. Mass.:
18011.66
Organism:
Homo sapiens (Human)
Description:
gi_4507785
Residue:
158
Sequence:
MSGIALSRLAQERKAWRKDHPFGFVAVPTKNPDGTMNLMNWECAIPGKKGTPWEGGLFKLRMLFKDDYPSSPPKCKFEPPLFHPNVYPSGTVCLSILEEDKDWRPAITIKQILLGIQELLNEPNIQDPAQAEAYTIYCQNRVEYEKRVRAQAKKFAPS
  
Inhibitor
Name:
BDBM61235
Synonyms:
(5Z)-2-anilino-5-[(3-bromo-5-methoxy-4-prop-2-enoxyphenyl)methylidene]-1,3-thiazol-4-one | (5Z)-2-anilino-5-[(3-bromo-5-methoxy-4-prop-2-enoxyphenyl)methylidene]-4-thiazolone | (5Z)-5-(4-allyloxy-3-bromo-5-methoxy-benzylidene)-2-anilino-2-thiazolin-4-one | (5Z)-5-[(3-bromanyl-5-methoxy-4-prop-2-enoxy-phenyl)methylidene]-2-phenylazanyl-1,3-thiazol-4-one | 5-(4-Allyloxy-3-bromo-5-methoxy-benzylidene)-2-phenylimino-thiazolidin-4-one | MLS001211829 | SMR000515991 | cid_5761729
Type:
Small organic molecule
Emp. Form.:
C20H17BrN2O3S
Mol. Mass.:
445.33
SMILES:
COc1cc(C=C2SC(Nc3ccccc3)=NC2=O)cc(Br)c1OCC=C |w:5.4,c:16|
Structure:
Search PDB for entries with ligand similarity: