Reaction Details Report a problem with these data
Target
Cell division control protein 42 homolog
Ligand
BDBM54699
Substrate
n/a
Meas. Tech.
Additional SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant
EC50
30000±n/a nM
Citation
 PubChem, PC Additional SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant PubChem Bioassay (2009)[AID] 
Target
Name:
Cell division control protein 42 homolog
Synonyms:
CDC42 | CDC42_HUMAN | Cell division control protein 42 homolog | G25K GTP-binding protein | cell division cycle 42 (GTP binding protein, 25kDa)
Type:
PROTEIN
Mol. Mass.:
21258.36
Organism:
Homo sapiens (Human)
Description:
ChEMBL_652970
Residue:
191
Sequence:
MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPPEPKKSRRCVLL
  
Inhibitor
Name:
BDBM54699
Synonyms:
4-(1-oxo-3-phenylprop-2-ynyl)benzonitrile | 4-(3-phenylprop-2-ynoyl)benzenecarbonitrile | 4-(3-phenylprop-2-ynoyl)benzonitrile | 4-(3-phenylpropioloyl)benzonitrile | UNM-0000306057 | cid_11708441
Type:
Small organic molecule
Emp. Form.:
C16H9NO
Mol. Mass.:
231.2488
SMILES:
O=C(C#Cc1ccccc1)c1ccc(cc1)C#N
Structure:
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