Reaction Details Report a problem with these data
Target
Ras-related protein Rab-7a
Ligand
BDBM54585
Substrate
n/a
Meas. Tech.
Oxadiazole SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype
EC50
30000±n/a nM
Citation
 PubChem, PC Oxadiazole SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype PubChem Bioassay (2009)[AID] 
Target
Name:
Ras-related protein Rab-7a
Synonyms:
GTP-binding protein (rab7) | RAB7 | RAB7A | RAB7A_CANLF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23519.50
Organism:
Canis lupus familiaris
Description:
gi_164058
Residue:
207
Sequence:
MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDVTAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDLENRQVATKRAQAWCYSKNNIPYFETSAKEAINVEQAFQTIARNALKQETEVELYNEFPEPIKLDKNDRAKTSAESCSC
  
Inhibitor
Name:
BDBM54585
Synonyms:
1-[4-(2,5-dimethylphenyl)-1-piperazinyl]-3-[5-(4-methoxyphenyl)-2-thiophenyl]-1-propanone | 1-[4-(2,5-dimethylphenyl)piperazin-1-yl]-3-[5-(4-methoxyphenyl)thiophen-2-yl]propan-1-one | 1-[4-(2,5-dimethylphenyl)piperazino]-3-[5-(4-methoxyphenyl)-2-thienyl]propan-1-one | KUC103449N | UNM-0000306166 | cid_44193700
Type:
Small organic molecule
Emp. Form.:
C26H30N2O2S
Mol. Mass.:
434.594
SMILES:
COc1ccc(cc1)-c1ccc(CCC(=O)N2CCN(CC2)c2cc(C)ccc2C)s1
Structure:
Search PDB for entries with ligand similarity: