Reaction Details Report a problem with these data
Target
Ras-related protein Rab-7a
Ligand
BDBM54677
Substrate
n/a
Meas. Tech.
Additional SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype
EC50
30000±n/a nM
Citation
 PubChem, PC Additional SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype PubChem Bioassay (2009)[AID] 
Target
Name:
Ras-related protein Rab-7a
Synonyms:
GTP-binding protein (rab7) | RAB7 | RAB7A | RAB7A_CANLF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23519.50
Organism:
Canis lupus familiaris
Description:
gi_164058
Residue:
207
Sequence:
MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDVTAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDLENRQVATKRAQAWCYSKNNIPYFETSAKEAINVEQAFQTIARNALKQETEVELYNEFPEPIKLDKNDRAKTSAESCSC
  
Inhibitor
Name:
BDBM54677
Synonyms:
(3E)-3-(1-ketoindan-2-ylidene)oxindole | (3E)-3-(3-oxidanylidene-1H-inden-2-ylidene)-1H-indol-2-one | (3E)-3-(3-oxo-1H-inden-2-ylidene)-1H-indol-2-one | UNM-0000305763 | cid_25220924
Type:
Small organic molecule
Emp. Form.:
C17H11NO2
Mol. Mass.:
261.2747
SMILES:
O=C1Nc2ccccc2\C1=C1\Cc2ccccc2C1=O
Structure:
Search PDB for entries with ligand similarity: