Reaction Details Report a problem with these data
Target
Ras-related protein Rab-7a
Ligand
BDBM54684
Substrate
n/a
Meas. Tech.
Additional SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype
EC50
30000±n/a nM
Citation
 PubChem, PC Additional SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype PubChem Bioassay (2009)[AID] 
Target
Name:
Ras-related protein Rab-7a
Synonyms:
GTP-binding protein (rab7) | RAB7 | RAB7A | RAB7A_CANLF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23519.50
Organism:
Canis lupus familiaris
Description:
gi_164058
Residue:
207
Sequence:
MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDVTAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDLENRQVATKRAQAWCYSKNNIPYFETSAKEAINVEQAFQTIARNALKQETEVELYNEFPEPIKLDKNDRAKTSAESCSC
  
Inhibitor
Name:
BDBM54684
Synonyms:
7-chloranyl-3-[3-(oxidanylamino)-1H-indol-2-yl]indol-2-one | 7-chloro-3-[3-(hydroxyamino)-1H-indol-2-yl]-2-indolone | 7-chloro-3-[3-(hydroxyamino)-1H-indol-2-yl]indol-2-one | UNM-0000305774 | cid_11845976
Type:
Small organic molecule
Emp. Form.:
C16H10ClN3O2
Mol. Mass.:
311.723
SMILES:
ONc1c([nH]c2ccccc12)C1=c2cccc(Cl)c2=NC1=O |c:13,21|
Structure:
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