Target
Ras-related protein Rab-7a
Ligand
BDBM54688
Substrate
n/a
Meas. Tech.
Additional SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype
EC50
30000±n/a nM
Citation
 PubChem, PC Additional SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype PubChem Bioassay (2009)[AID] 
Target
Name:
Ras-related protein Rab-7a
Synonyms:
GTP-binding protein (rab7) | RAB7 | RAB7A | RAB7A_CANLF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23519.50
Organism:
Canis lupus familiaris
Description:
gi_164058
Residue:
207
Sequence:
MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDVTAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDLENRQVATKRAQAWCYSKNNIPYFETSAKEAINVEQAFQTIARNALKQETEVELYNEFPEPIKLDKNDRAKTSAESCSC
  
Inhibitor
Name:
BDBM54688
Synonyms:
2-amino-5-(4-bromobenzoyl)-1-(4-methoxyphenyl)sulfonyl-4-phenyl-pyrrole-3-carbonitrile | 2-amino-5-(4-bromobenzoyl)-1-(4-methoxyphenyl)sulfonyl-4-phenylpyrrole-3-carbonitrile | 2-amino-5-[(4-bromophenyl)-oxomethyl]-1-(4-methoxyphenyl)sulfonyl-4-phenyl-3-pyrrolecarbonitrile | 2-azanyl-5-(4-bromophenyl)carbonyl-1-(4-methoxyphenyl)sulfonyl-4-phenyl-pyrrole-3-carbonitrile | UNM-0000305778 | cid_25220929
Type:
Small organic molecule
Emp. Form.:
C25H18BrN3O4S
Mol. Mass.:
536.397
SMILES:
COc1ccc(cc1)S(=O)(=O)n1c(N)c(C#N)c(c1C(=O)c1ccc(Br)cc1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: