Reaction Details Report a problem with these data
Target
Ras-related C3 botulinum toxin substrate 1
Ligand
BDBM50218889
Substrate
n/a
Meas. Tech.
Additional SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac1 activated mutant
EC50
30000±n/a nM
Citation
 PubChem, PC Additional SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac1 activated mutant PubChem Bioassay (2009)[AID] 
Target
Name:
Ras-related C3 botulinum toxin substrate 1
Synonyms:
RAC1_MOUSE | Rac1 | Rac1 protein
Type:
PROTEIN
Mol. Mass.:
21455.91
Organism:
Mus musculus
Description:
EBI_101485
Residue:
192
Sequence:
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL
  
Inhibitor
Name:
BDBM50218889
Synonyms:
7-chloroindirubin | CHEMBL243777 | cid_11847137
Type:
Small organic molecule
Emp. Form.:
C16H9ClN2O2
Mol. Mass.:
296.708
SMILES:
Clc1cccc2C(C(=O)Nc12)=C1Nc2ccccc2C1=O |w:11.13|
Structure:
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